Job Description

The Toxicology Senior Research Fellow acts as the Preclinical Safety Assessment (PSA) lead on Research project teams, cross-site teams and steering committees and is accountable for overall project and often disease area and/or site strategy supporting safety assessment of novel molecules and therapies advancing through the Vertex discovery pipeline into early development. The incumbent functions as part of cross-functional project teams and designs appropriate safety in vivo and in vitro safety studies to support advancement of project compounds/therapies from the candidate nomination stage. The incumbent is also accountable for site safety strategy and plays an integrated role in research site scientific leadership. Key Duties and Responsibilities: Develops a broad and deep understanding of the disease area, target biology and chemical space for all Research programs at their resident site. Applies insight and knowledge to influence research strategy and target selection. Independently develops the strategy for early safety assessment and support for multiple programs from target selection to the VXc milestone and aligns with PSA leadership. Collaborates with cross-functional and cross-site partners to develop safety strategies tailored to the portfolio at their resident site. Acts as a liaison between the project teams and other PSA subfunctions to arrange required studies and profiling assays and communicates results to the project team and site management with appropriate interpretation. Works with PSA study monitors to provide scientific oversight of external studies at CROs/partner organizations and communicates significant findings and study events to supervisors and PSA leadership in a timely manner. Collaborates closely with the program regulatory toxicologists to ensure a smooth transition into development at the VXc milestone. Prepares high quality reports and presentations to clearly communicate study plans and results to peers, management and project teams. Keeps up to date with current literature and emerging industry trends in general pharmaceutical toxicology and therapeutics. Participates in relevant continuing education activities and drives own professional development. Acts as an opinion leader and mentor to other toxicologists and cross-disciplinary research scientists. Knowledge and Skills: Subject matter expertise in toxicology and the design and interpretation of in vivo studies in common preclinical species. In-depth knowledge of animal husbandry and animal welfare issues. Excellent data processing and statistical skills. Excellent written, verbal communications and influencing skills. Microsoft Office Suite or equivalent office productivity tools. DABT certification preferred. Education and Experience: Bachelor’s, Master’s or Doctoral degree in life sciences or chemistry. Bachelors degree and 20 years experience or Masters degree and 15 years experience or PhD and 11 years experience. Pay Range: $229,600 - $344,400. Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible. Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

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