Job Description

Position We are seeking a talented and highly motivated scientist with a strong background and hands-on experience in bioconjugation to join our Discovery Chemistry team. In this laboratory-based position, you will play a pivotal role in the development of cutting-edge Degrader-Antibody Conjugates (DACs) across various therapeutic areas. The successful candidate will have the opportunity to directly contribute to the following key platform operations : Develop, optimize and implement high-throughput bioconjugation processes through the application of established and state-of-the-art technologies Execute high-throughput preparation of novel antibody drug conjugates at milligram scale Contribute to the design and synthesis of linkers and linker-payloads to enhance conjugate properties Prepare, purify and characterize bioconjugates to support in-vitro and in-vivo studies Contribute to the collaborative efforts focused on the development and optimization of bioanalytical protocols to evaluate critical quality attributes of DACs Engage in cross-functional discussions and contribute to scientific strategies and team goals focused on advancing Nurix’s Degrader-Antibody Conjugate (DAC) discovery programs Prepare reports and present data at internal group meetings Education and Experience Ph.D. in Organic Chemistry, Chemical Biology, Biochemistry, or related field with up to 4 years relevant experience OR MS with 6+ years relevant experience, OR BS or equivalent with 10+ years relevant experience Experience with high-throughput automated workflows to produce bioconjugates Hands-on laboratory experience in carrying out diverse conjugation chemistry protocols, linker-payload synthesis and related processes to produce high-quality drug conjugates Familiar with the general workflow operations, instrumentation and practices used for the generation of antibody-drug conjugates Experience characterizing and purifying bioconjugates using common analytical tools Experience working in the drug discovery chemistry field – linker design, synthesis, and SAR based property optimization of small molecules Established track record of conference presentations and peer-reviewed publications in the areas of antibody drug conjugation and organic synthesis Strong written and verbal communication skills Added Quantifications Postdoctoral or industrial work experience in the bioconjugation field Experience working in Antibody-Drug Conjugate (ADC)- or Degrader-Antibody Conjugate (DAC)- based drug discovery programs Experience working with bioanalytical tools such as hydrophobic interaction chromatography (HIC), preparative-scale size exclusion chromatography (SEC), liquid chromatography-mass spectrometry (LC-MS), ion-exchange (IEX), and reversed phase (RP)-HPLC, Nuclear Magnetic Resonance (NMR) Spectroscopy Experience carrying out assays to evaluate in-vitro stability of ADC and payloads such as Cathepsin B, esterase activity and free drug analysis Fit with Nurix Culture and Values Strong team orientation and highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy. #J-18808-Ljbffr Nurix Therapeutics

Job Tags

Similar Jobs